Endocrine Abstracts

Introduction: Patients with permanent hypoparathyroidism receiving conventional treatment have increased risk of subcapsular cataracts, basal ganglia calcifications, urolithiasis and renal insufficiency. The aim of this study was to assess the prevalence and the interfering factors of these complications in patients with permanent hypoparathyroidism.Methods: We conducted a cross-sectional study including 53 patients with permanent hyperparathyroidism. Bi...

Introduction: Patients with permanent hypoparathyroidism suffer from multiple complaints and are exposed to long-term complications that compromise their well-being. The aim of our study was to assess the quality of life in patients with permanent hypoparathyroidism receiving conventional vitaminocalcic therapy.Methods: We conducted a cross-sectional case-control study including 53 patients with permanent hypoparathyroidism and 53 age-sex-body mass index...

Introduction: Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with diverse manifestations. Patients with NF1 are particularly prone to developing tumors of the central nervous system (CNS) and endocrine disorders. Herein we report a case of pituitary hyperplasia in a woman with NF1.Observation: A 55-year-old woman was referred to our department for the exploration of recurrent hypoglycemia. Her past medical history included NF1, asthma t...

IntroductionPrimary hyperaldosteronism (PHA) is an increasingly prevalent cause of endocrine hypertension. It is characterized by unregulated aldosterone secretion with an excessive activation of mineralocorticoid receptors, inducing volume expansion, hypokalemia, endothelial dysfunction and fibrotic processes in the renal and cardiovascular systems. The aim of this study was to assess the metabolic, renal, and cardiovascular status in patients with prim...

IntroductionPrimary hyperaldosteronism (PHA) represents the most common cause of secondary hypertension. It is associated with a high risk of cardiovascular diseases (CVD), suggesting that aldosterone is implicated in the development of early atherosclerosis. Clinical studies have shown that atherogenic index of plasma (AIP) predicts cardiovascular risk. The aim of this study was to assess the associations between atherogenic index of plasma and cardiova...

Introduction: The diagnosis of primary hyperparathyroidism and hypoparathyroidism is still challenging because of the increasing frequency of non-classical presentations. The calcium-to-phosphorus ratio (Ca/P) (CPR) is an inexpensive biochemical marker that could be useful to diagnose parathyroid disorders.Aim: The aim of this study was to assess the performances of CPR in the diagnosis of primary hyperparathyroidism and hypoparathyroidism.<p class="...

Introduction: Primary hypothyroidism is a common condition. Its treatment is simple and consists of daily levothyroxine intake. Cases with refractory hypothyroidism despite high doses of levothyroxine were reported. Herein, we report the case of a patient with refractory hypothyroidism secondary to gastrointestinal malabsorption that was improved by L-thyroxine liquid oral substitution.Observation: A 49-year-old woman was admitted for refractory hypothyr...

Introduction: Gougerot disease is an autoimmune disorder characterized by the lymphoid infiltration of salivary and lachrymal glands leading to the two most common symptoms dry eyes and a dry mouth. Primary hyperparathyroidism (PHPT), one of the most common endocrine disorders, is usually diagnosed by the association of hypercalcemia and parathyroid hormone (PTH) levels that are either elevated or inappropriately normal. The association of PHPT with Gougerot disease is rare, o...

IntroductionFahr’s syndrome (FS) is a rare neurodegenerative disorder. It’s characterized by abnormal calcifications in basal ganglia and cerebral cortex inducing neuropsychiatric disorders and cognitive impairment. The aim of our study was to assess the prevalence of FS, its characteristics, and its associated factors in patients with permanent hypoparathyroidism.MethodsWe conducted a cross-section...

Introduction: Pheochromocytomas are rare catecholamine-secreting tumors presenting with various clinical manifestations. Hypertension is the most common finding in pheochromocytomas. It can be either persistent or paroxysmal. Study Design: We conducted a retrospective study of 34 patients who were admitted into the endocrinology department of Charles Nicolle hospital, with a diagnosis of a pheochromocytoma from January 2005 to November 2022.Results: Twen...